Stem Cells in the Treatment of Renal Allograft Diseases
Keywords:
renal failure, mesenchymal stem cells, renal allograft
Abstract
In recent years, there has been growing interest in the use of stem cells as a therapeutic agent for the restoration of the damaged tissues and organs.
We present a clinical case. Male, 39 y.o. Diagnosis: Glomerulonephritis. On 10/09/2012, he underwent heterotopic renal allotransplantation from a live relative donor. On 09/23/2020, he was admitted to the hospital due to renal allograft pyelonephritis. On 10/28/2020, a cell based donor umbilical cord blood product was infused. Cell therapy enabled to minimize the consequences of the graft damage, to preserve the graft function and satisfactory condition of the recipient.
References
- Rota C, Morigi M, Cerullo D, Introna M, Colpani O, Corna D, Capelli C, Rabelink TJ, Leuning DG, Rottoli D, Benigni A, Zoja C, Remuzzi G. Therapeutic potential of stromal cells of non-renal or renal origin in experimental chronic kidney disease. Stem Cell Res Ther. 2018 Aug 14;9(1):220. https://doi.org/10.1186/s13287-018-0960-8
- Ninichuk V, Gross O, Segerer S, Hoffmann R, Radomska E, Buchstaller A, Huss R, Akis N, Schlöndorff D, Anders HJ. Multipotent mesenchymal stem cells reduce interstitial fibrosis but do not delay progression of chronic kidney disease in collagen4A3-deficient mice. Kidney Int. 2006;70(1):121-129. https://doi.org/10.1038/sj.ki.5001521
- Trounson A, DeWitt ND. Pluripotent stem cells progressing to the clinic. Nat Rev Mol Cell Biol. 2016 Mar;17(3):194-200. https://doi.org/10.1038/nrm.2016.10
- Blanpain C, Fuchs E. Stem cell plasticity. Plasticity of epithelial stem cells in tissue regeneration. Science. 2014 Jun 13;344(6189):1242281. https://doi.org/10.1126/science.1242281
- Imberti B, Morigi M, Tomasoni S, Rota C, Corna D, Longaretti L, Rottoli D, Valsecchi F, Benigni A, Wang J, Abbate M, Zoja C, Remuzzi G. Insulin-like growth factor-1 sustains stem cell mediated renal repair. J Am Soc Nephrol. 2007 Nov;18(11):2921-2928. https://doi.org/10.1681/ASN.2006121318
- Tögel F, Zhang P, Hu Z, Westenfelder C. VEGF is a mediator of the renoprotective effects of multipotent marrow stromal cells in acute kidney injury. J Cell Mol Med. 2009 Aug;13(8B):2109-2114. https://doi.org/10.1111/j.1582-4934.2008.00641.x
- Tögel F, Hu Z, Weiss K, Isaac J, Lange C, Westenfelder C. Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol. 2005 Jul;289(1):F31-42. https://doi.org/10.1152/ajprenal.00007.2005
- Squillaro T, Peluso G, Galderisi U. Clinical Trials With Mesenchymal Stem Cells: An Update. Cell Transplant. 2016;25(5):829-48. https://doi.org/10.3727/096368915X689622
- Chapel A, Bertho JM, Bensidhoum M, Fouillard L, Young RG, Frick J, Demarquay C, Cuvelier F, Mathieu E, Trompier F, Dudoignon N, Germain C, Mazurier C, Aigueperse J, Borneman J, Gorin NC, Gourmelon P, Thierry D. Mesenchymal stem cells home to injured tissues when co-infused with hematopoietic cells to treat a radiation-induced multi-organ failure syndrome. J Gene Med. 2003 Dec;5(12):1028-1038. https://doi.org/10.1002/jgm.452
- Mahmood A, Lu D, Lu M, Chopp M. Treatment of traumatic brain injury in adult rats with intravenous administration of human bone marrow stromal cells. Neurosurgery. 2003 Sep;53(3):697-702; discussion 702-3. https://doi.org/10.1227/01.neu.0000079333.61863.aa
- Morigi M, Rota C, Montemurro T, Montelatici E, Lo Cicero V, Imberti B, Abbate M, Zoja C, Cassis P, Longaretti L, Rebulla P, Introna M, Capelli C, Benigni A, Remuzzi G, Lazzari L. Life-sparing effect of human cord blood-mesenchymal stem cells in experimental acute kidney injury. Stem Cells. 2010 Mar 31;28(3):513-22. https://doi.org/10.1002/stem.293
Published
2021-10-27
How to Cite
Nikonenko, O., Rusanov, I. V., Nykonenko, T. N., & Vildanov, S. R. (2021). Stem Cells in the Treatment of Renal Allograft Diseases. Transplantation and Artificial Organs, (2 (03), 78-83. https://doi.org/10.30702/transpaorg/10_21.2710/0278-83/576.3/4
Section
SCIENTIFIC PUBLICATIONS